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1

Scale-up and blender change model for the pharmaceutical lubricated mixing process

Suzuki, Yasuhiro, Kato, Takafumi, Kikkawa, Yoshito, Suzuki, Tatsuya, Wakiyama, Naoki, Terada, Katsuhide

Journal:

Powder Technology

Year:

2015

Language:

english

File:

PDF, 858 KB

english, 2015

2

Valvular heart disease

Keiji Ataka, Masayoshi Okada, Chojiro Yamashita, Teruo Yamashita, Hidetaka Wakiyama, Keitaro Nakagiri, Naoki Yoshimura

Journal:

General Thoracic and Cardiovascular Surgery

Year:

1999

Language:

english

File:

PDF, 551 KB

english, 1999

3

Solid State Radical Recombination and Charge Transfer across the Boundary between Indomethacin and Silica under Mechanical Stress

Tomoyuki Watanabe, Susumu Hasegawa, Naoki Wakiyama, Fusao Usui, Akira Kusai, Tetsuhiko Isobe, Mamoru Senna

Journal:

Journal of Solid State Chemistry

Year:

2002

Language:

english

File:

PDF, 219 KB

english, 2002

4

Stability of amorphous indomethacin compounded with silica

Tomoyuki Watanabe, Naoki Wakiyama, Fusao Usui, Masaru Ikeda, Tetsuhiko Isobe, Mamoru Senna

Journal:

International Journal of Pharmaceutics

Year:

2001

Language:

english

File:

PDF, 191 KB

english, 2001

5

Stabilization of amorphous indomethacin by co-grinding in a ternary mixture

Tomoyuki Watanabe, Ikumasa Ohno, Naoki Wakiyama, Akira Kusai, Mamoru Senna

Journal:

International Journal of Pharmaceutics

Year:

2002

Language:

english

File:

PDF, 457 KB

english, 2002

6

Prediction of apparent equilibrium solubility of indomethacin compounded with silica by 13C solid state NMR

Tomoyuki Watanabe, Susumu Hasegawa, Naoki Wakiyama, Akira Kusai, Mamoru Senna

Journal:

International Journal of Pharmaceutics

Year:

2002

Language:

english

File:

PDF, 214 KB

english, 2002

7

Solid phase transition of CS-891 enantiotropes during grinding

Shuichi Yada, Masaoki Ohya, Yuko Ohuchi, Takeshi Hamaura, Naoki Wakiyama, Fusao Usui, Akira Kusai, Keiji Yamamoto

Journal:

International Journal of Pharmaceutics

Year:

2003

Language:

english

File:

PDF, 202 KB

english, 2003

8

Prevalence of a Streptococcal Inhibitor of a Complement-Mediated Cell lysis-like Gene (sicG) inStreptococcus Dysgalactiaesubsp. Equisimilis

Masaaki Minami, Mariko Ichikawa, Hideyuki Matsui, Nanako Hata, Naoki Wakiyama, Masakado Matsumoto, Michio Ohta, Tadao Hasegawa

Journal:

Current Microbiology

Year:

2011

Language:

english

File:

PDF, 198 KB

english, 2011

9

A retrospective study of the epidemiology ofClostridiumdifficileinfection at a University Hospital in Japan: genotypic features of the isolates and clinical characteristics of the patients

Yasuhito Iwashima, Atsushi Nakamura, Haru Kato, Hideaki Kato, Yukio Wakimoto, Naoki Wakiyama, Chiharu Kaji, Ryuzo Ueda

Journal:

Journal of Infection and Chemotherapy

Year:

2010

Language:

english

File:

PDF, 237 KB

english, 2010

10

Comparison between polyvinylpyrrolidone and silica nanoparticles as carriers for indomethacin in a solid state dispersion

Tomoyuki Watanabe, Susumu Hasegawa, Naoki Wakiyama, Akira Kusai, Mamoru Senna

Journal:

International Journal of Pharmaceutics

Year:

2003

Language:

english

File:

PDF, 125 KB

english, 2003

11

Successful surgical treatment of an Edwards type IIIB right aortic arch aneurysm: Report of a case

Hidetaka Wakiyama, Masayoshi Okada, Chojiro Yamashita, Keitaro Nakagiri, Naoki Yoshimura, Masato Yoshida, Keiji Ataka, Takaki Sugimoto

Journal:

Year:

1998

Language:

english

File:

PDF, 258 KB

english, 1998

12

Mechanism of caking of granules containing oily materials

Naoki Wakiyama, Akira Kusai, Kenji Nishimura

Journal:

International Journal of Pharmaceutics

Year:

1992

Language:

english

File:

PDF, 612 KB

english, 1992

13

Fc domain mediated self-association of an IgG1 monoclonal antibody under a low ionic strength condition

Hirotaka Nishi, Makoto Miyajima, Naoki Wakiyama, Kei Kubota, Jun Hasegawa, Susumu Uchiyama, Kiichi Fukui

Journal:

Journal of Bioscience and Bioengineering

Year:

2011

Language:

english

File:

PDF, 463 KB

english, 2011

14

A molecular orbital study on the chemical interaction across the indomethacin/silica interparticle boundary due to mechanical stressing

Tomoyuki Watanabe, Naoki Wakiyama, Akira Kusai, Mamoru Senna

Journal:

Powder Technology

Year:

2004

Language:

english

File:

PDF, 327 KB

english, 2004

15

Open Distal Anastomosis in Retrograde Cerebral Perfusion for Repair of Ascending Aortic Dissection

Chojiro Yamashita MD, Masayoshi Okada MD, Keiji Ataka MD, Masato Yoshida MD, Naoki Yoshimura MD, Takashi Azami MD, Keitarou Nakagiri MD, Hidetaka Wakiyama MD, Teruo Yamashita MD

Journal:

The Annals of Thoracic Surgery

Year:

1997

Language:

english

File:

PDF, 271 KB

english, 1997

16

Real-time monitoring of lubrication properties of magnesium stearate using NIR spectrometer and thermal effusivity sensor

Nakagawa, Hiroshi, Kano, Manabu, Hasebe, Shinji, Suzuki, Tatsuya, Wakiyama, Naoki

Journal:

International Journal of Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 1.10 MB

english, 2013

17

Determination for dry layer resistance of sucrose under various primary drying conditions using a novel simulation program for designing pharmaceutical lyophilization cycle

Kodama, Tatsuhiro, Sawada, Hiroyuki, Hosomi, Hiroshi, Takeuchi, Masahito, Wakiyama, Naoki, Yonemochi, Etsuo, Terada, Katsuhide

Journal:

International Journal of Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 606 KB

english, 2013

18

Optimization of secondary drying condition for desired residual water content in a lyophilized product using a novel simulation program for pharmaceutical lyophilization

Kodama, Tatsuhiro, Takeuchi, Masahito, Wakiyama, Naoki, Terada, Katsuhide

Journal:

International Journal of Pharmaceutics

Year:

2014

Language:

english

File:

PDF, 1.25 MB

english, 2014

19

Verification of model development technique for NIR-based real-time monitoring of ingredient concentration during blending

Nakagawa, Hiroshi, Kano, Manabu, Hasebe, Shinji, Miyano, Takuya, Watanabe, Tomoyuki, Wakiyama, Naoki

Journal:

International Journal of Pharmaceutics

Year:

2014

Language:

english

File:

PDF, 1.21 MB

english, 2014

20

The role of light anhydrous silicic acid on physical stability of troglitazone solid dispersion under humidified conditions

Nakahashi, Toshiyuki, Matsumoto, Takahiro, Wakiyama, Naoki, Moribe, Kunikazu, Yamamoto, Keiji

Journal:

Advanced Powder Technology

Year:

2014

Language:

english

File:

PDF, 1.31 MB

english, 2014

21

Aluminum elution and precipitation in glass vials: effect of pH and buffer species

Ogawa, Toru, Miyajima, Makoto, Wakiyama, Naoki, Terada, Katsuhide

Journal:

Drug Development and Industrial Pharmacy

Year:

2015

Language:

english

File:

PDF, 356 KB

english, 2015

22

Duration of the local anesthetic effect of tetracaine hydrochloride solutions and tetracaine in microspheres.

WAKIYAMA, NAOKI, JUNI, KAZUHIKO, NAKANO, MASAHIRO

Journal:

Journal of Pharmacobio-Dynamics

Year:

1982

File:

PDF, 535 KB

1982

23

Preparation and evaluation in vitro of polylactic acid microspheres containing local anesthetics.

WAKIYAMA, NAOKI, JUNI, KAZUHIKO, NAKANO, MASAHIRO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1981

File:

PDF, 1.07 MB

1981

24

Influence of physicochemical properties of polylactic acid on the characteristics and in vitro release patterns of polylactic acid microspheres containing local anesthetics.

WAKIYAMA, NAOKI, JUNI, KAZUHIKO, NAKANO, MASAHIRO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1982

File:

PDF, 2.25 MB

1982

25

Preparation and evaluation in vitro and in vivo of polylactic acid microspheres containing dibucaine.

WAKIYAMA, NAOKI, JUNI, KAZUHIKO, NAKANO, MASAHIRO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1982

File:

PDF, 2.12 MB

1982

26

Do Amorphous Troglitazones Prepared from Two Diastereomer-Pairs Have the Same Molecular Mobility and Crystallization Rate at the Surface?

Furuyama, Naho, Hasegawa, Susumu, Yada, Shuichi, Hamaura, Takeshi, Wakiyama, Naoki, Yonemochi, Etsuo, Terada, Katsuhide, Buckton, Graham

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2011

Language:

english

File:

PDF, 3.93 MB

english, 2011

27

Development of a Rapid Process Monitoring Method for Dry-Coated Tableting Process by Using Near-Infrared Spectroscopy

Ito, Masatomo, Suzuki, Tatsuya, Wakiyama, Naoki, Teramoto, Hiroshi, Yonemochi, Etsuo, Terada, Katsuhide

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2011

Language:

english

File:

PDF, 781 KB

english, 2011

28

Chemical Mapping of Hydration and Dehydration Process of Theophylline in Tablets Using Terahertz Pulsed Imaging

Hisazumi, Jin, Suzuki, Tatsuya, Wakiyama, Naoki, Nakagami, Hiroaki, Terada, Katsuhide

Year:

2012

Language:

english

File:

PDF, 1.65 MB

english, 2012

29

Using Terahertz Reflectance Spectroscopy to Quantify Drug Substance in Tablets

Hisazumi, Jin, Watanabe, Tomoyuki, Suzuki, Tatsuya, Wakiyama, Naoki, Terada, Katsuhide

Year:

2012

Language:

english

File:

PDF, 1.06 MB

english, 2012

30

Optimization of Primary Drying Condition for Pharmaceutical Lyophilization Using a Novel Simulation Program with a Predictive Model for Dry Layer Resistance

Kodama, Tatsuhiro, Sawada, Hiroyuki, Hosomi, Hiroshi, Takeuchi, Masahito, Wakiyama, Naoki, Yonemochi, Etsuo, Terada, Katsuhide

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2014

Language:

english

File:

PDF, 658 KB

english, 2014

31

Effects of Phosphate Buffer in Parenteral Drugs on Particle Formation from Glass Vials

Ogawa, Toru, Miyajima, Makoto, Wakiyama, Naoki, Terada, Katsuhide

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2013

Language:

english

File:

PDF, 1.58 MB

english, 2013

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